ODCs

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2 OMIM references -
1 associated gene
10 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

1 OMIM reference -
1 associated gene
6 signs/symptoms

Fibronectin glomerulopathy

Alpha-1-antitrypsin deficiency


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	FN1	(0.63)	SERPINA1

Citations in the biomedical literature:

Fibronectin glomerulopathy		Alpha-1-antitrypsin deficiency
	Synonym(s): - GFND - Glomerulopathy with fibronectin deposits		Synonym(s): (no synonyms)

	Classification (Orphanet): - Rare genetic disease - Rare renal disease		Classification (Orphanet): - Inborn errors of metabolism - Rare genetic disease - Rare hepatic disease - Rare renal disease - Rare respiratory disease

	Classification (ICD10): - Diseases of the genitourinary system -		Classification (ICD10): - Endocrine, nutritional and metabolic diseases -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: variable Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: 1-5 / 10 000 Average age onset: variable Average age of death: - Type of inheritance: autosomal recessive

	External references: 2 OMIM references - No MeSH references		External references: 1 OMIM reference - 2 MeSH references: C531610 / D019896

Fibronectin glomerulopathy		Alpha-1-antitrypsin deficiency
	Very frequent - Autosomal dominant inheritance - Chronic arterial hypertension - Edema of the legs / lower limbs - Functional anomalies of the kidney and the urinary tract - Hematuria / microhematuria - Proteinuria - Renal failure - Renal glomerular defect / glomerulopathy Occasional - Intracranial / cerebral / meningeal hemorrhage		Very frequent - Autosomal recessive inheritance - Emphysema - Hepatocellular liver disease / hepatic failure Frequent - Hepatitis / icterus / cholestasis - Hepatomegaly / liver enlargement (excluding storage disease)